Relationship between Microalbuminuria and Disease Activity in Patients with Ulcerative Colitis

Abstract

BACKGROUND:

Introducing a non-invasive method for determining disease activity is important in patients with ulcerative colitis (UC). So in this study, we aimed to assess the association between disease activity index and microalbuminuria in patients with UC.

METHODS:

 In the present cross-sectional study, 84 patients with UC were selected. The disease activity was calculated by the partial Mayo clinic score. Microalbuminuria was assessed using the immunoturbidimetric method in a first-voided sample in the morning in two consecutive days and the mean of these two measurements was reported as urinary microalbumin level. Serum C reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fecal calprotectin were measured respectively using conventional turbidimetric immunoassay, Westergren method, and ELISA methods.

RESULTS:

The mean age of the participants was 40.01±12.85 years, 60.8% of them were female and 53.5% had microalbuminuria. The frequency of microalbuminuria was significantly higher in patients with active compared with inactive inflammatory bowel disease (IBD). There were significant differences between the patients with active and inactive disease regarding CRP, ESR, and calprotectin (p< 0.001). Moreover, there was a strong correlation between microalbuminuria and CRP (r= 0.89, p <0.001), ESR (r=0.92, p <0.001), and calprotectin (r=0.91, p <0.001).

CONCLUSIONS:

Microalbuminuria could be used as a non-invasive marker of disease activity in patients with UC.