Evaluation of the Prevalence of Anti-Transglutaminase 2 and 6 Antibodies in Patients with Sero-Positive Multiple Sclerosis

Mohammad Hassan Emami, Mohammad Reza Najafi, Sepideh Allahdadian, Samane Mohammadzadeh, Nahid Jamali, Anasik Lalazarian, Vahid Shaygan nejad, Fatemeh Maghool



Gluten sensitivity (GS) is one of the gluten-related disorders (GRDs). Patients with GS may have serum antibodies against tissue transglutaminase (tTG) (IgA and IgG) without any evidence of enteropathy. We aimed to evaluate both tTG-6 and tTG-2 antibodies to determine the prevalence of seropositive tTG-2 and tTG-6 antibodies in patients with multiple sclerosis (MS).


In this cross-sectional study, we carried out serological tests (IgA & IgG anti-tTG-6 and tTG-2 antibodies) in patients with MS.


 72 patients with MS were included in this study. Of them, seropositive patients for total (IgA+IgG) of tTG-6 and tTG-2 autoantibodies were 9.7% (95% CI, 4.2-18) and 5.6% (95% CI, 1.4-12.5), respectively. 


 Anti-tTG-6 antibody testing may be necessary for early diagnosis of GS in patients with MS. More studies with larger sample sizes are warranted to confirm these data.


Gluten sensitivity, Multiple sclerosis, transglutaminase

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DOI: http://dx.doi.org/10.15171/middle%20east%20j%20di.v16i1.3056

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