Evaluation of Hematological Parameters as Markers for Subclinical Inflammation in Adults with Familial Mediterranean Fever

Abstract

Background:

Repeated polyserositis, another name for familial Mediterranean fever (FMF), is an autoimmune disorder with an autosomal recessive nature primarily characterized by short-lived repeated periods of peritonitis, pleuritis, and arthritis, generally accompanied by fever.

Methods:

Our participants were divided into two groups. Group I (patients): 100 individuals who were diagnosed  as patients with FMF and were monitored. Group II (control): matched- healthy individuals (100 controls). They were compared and followed up as regards demographic, clinical, and laboratory data: routine investigations, neutrophil/lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and mean packed volume (MPV), red cell distribution width (RDW), C-reactive protein (CRP), and erytherocyte sedmintation rate(ESR).

Results:

Group I: MPV mean was 12.03±2.89, whereas group II MPV mean was 7.74±0.57. MPV was significantly statistically greater in group I than in group II. RDW mean in group I was 17.07±1.39 and in group II was 12.92±0.63. RDW was also significantly statistically greater in group I compared with group II. Group I's NLR mean was 3.05±0.71, whereas group II's NLR mean was 1.75±0.2. PLR mean in group I was 164.8±122.8 and in group II was 111.26±29.16.

Conclusion:

A statistically significant association was shown between the diagnosis of adult FMF and NLR, PLR, MPV, and RDW.