Outcome of Cytomegalovirus Colitis in Inflammatory Bowel Disease with Different Regimes of Ganciclovir

Iftikhar Ahmed, Wael Kassem, Yazen Salam, Manuele Furnari, Tina Mehta

Abstract


BACKGROUND

Cytomegalovirus (CMV) infection is common in individuals with inflammatory bowel disease (IBD) and is responsible for relapse, increased severity, and poor outcome if left untreated. Ganciclovir is the mainstay of treatment but data regarding its use, mode of administration, and duration of treatment is poorly described. We reviewed the practice of treating CMV colitis with different regimes of ganciclovir at a district NHS hospital to compare the clinical outcome.

 

METHODS

35 patients with IBD and concurrent diagnosis of CMV infection were evaluated. The parameters studied were clinical outcome in term of clinical response, length of hospital stay, readmission, or colectomy with three different regimes of ganciclovir, in addition to treatment for IBD.

 

RESULTS

35 patients with IBD (ulcerative colitis=23, Crohn’s disease=5, Indeterminate colitis=7) and positive diagnosis of CMV infection were studied. Clinical outcome with two weeks of intravenous (IV) ganciclovir regime was superior than one week of IV ganciclovir and two weeks of oral Valganciclovir in term of clinical response on day 15 (95.8% vs 74%, 24.3%, respectively p=0.45) and colectomy rate within 3 months (6.25% vs 27.3%, vs 25%, respectively).

 

CONCLUSION

CMV colitis is associated with poor outcome in patient with IBD if left untreated. 2 weeks IV ganciclovir was associated with a better outcome than 1 week of IV treatment or oral treatment.


Keywords


Cytomegalovirus colitis, Inflammatory bowel disease, Indeterminate colitis, Ganciclovir

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DOI: http://dx.doi.org/10.15171/middle%20east%20j%20di.v10i4.1990