Repository of Human Blood Derivative Biospecimens in Biobank: Technical Implications

Ashraf Mohamadkhani, Hossein Poustchi

Abstract


 

Human biorepositories are collection of biological samples and health information from a large number of participants generally in the cohort studies. The main purpose of established biobanks is organization of biomedical research for upgrading the knowledge of human disorders from cancer to infectious and rare disease. The studies of generation relationships and understanding the preclinical stages of ageing are also from the solution of bitobank.

This review overview the significance and storage condition of biospecimens including whole blood, red blood cells (RBC), buffy coat, plasma, serum, DNA and RNA that derived from blood in human biobanks. These biological samples provide valuable information on the prevalence of germline mutations, epigenetic modifications or interaction between genes and proteins in associated with the development of certain types of disease. The quality of biospecimen in biobanks is a powerful tool for valid identification of biomarkers. Therefore optimum qualities of human biological samples in long time storage that have been assessed in several studies also indicate in this review.

 


Keywords


Whole blood; Buffy coat; Plasma; Serum; DNA; Biobank

Full Text:

PDF


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.