Target Antigens for Perinuclear Antineutrophil Cytoplasmic Antibodies in Iranian Patients with Ulcerative Colitis

Ali Bahari, Mahmoud Aarabi, Mehdi Hedayati, Ali Jarollahi, Farzad Firouzi, Rahim Aghazadeh, Mohammad Reza Zali, Zohreh Bari, Mohammad Hashemi, Abbas Esmaeilzadeh, Ali Mokhtarifar, Azita Ganji



Patients with ulcerative colitis (UC) carry autoantibodies such as perinuclear antineutrophil cytoplasmic antibodies (p-ANCA).

Objective: The aim of the present study was to evaluate the target antigens for p-ANCA in Iranian patients with UC.


p-ANCA target antigens including elastase, lactoferrin, cathepsin G, myeloproxidase, lysozyme, and bactericidal permeability increasing protein (BPI) were determined in 113 patients with UC using enzyme-linked immunosorbent assay (ELISA).


59.2% of the patients were positive for at least one antigen and p-ANCA directed against lactoferrin, elastase, lysozyme, cathepsin G, BPI, and myeloproxidase in 31.5%, 25.9%, 8.3%, 7.4%, 5.6%, and 0% of the patients, respectively.


The highest prevalence of p-ANCA was observed against lactoferrin and elastase. Also, myeloproxidase was not an antigen for p-ANCA among our patients.


Inflammatory bowel disease; Ulcerative colitis; Anti-neutrophil cytoplasmic antibody; Ttarget antigen

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